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. Plasma renin activity (a) and plasma aldosterone (b) levels (b1) and baseline–endpoint change (b2) following 8 weeks of treatment with placebo, valsartan, nebivolol, or the single-pill combination. Neb, nebivolol; PRA, plasma renin activity; SPC, single-pill combination; Val, valsartan. Modified with permission from [80]. ∗ P < 0.05; ∗∗∗ P < 0.001.
