Table III. The top five up- and down-regulated chemokine and cytokine transcripts for each treatment condition.

Profiles were generated by contrasting treatment against negative controls. Positive FC indicates up-regulation, whereas negative (−) FC indicates down-regulation. Gray shaded boxes highlight the expression pattern of IFNα and IFNγ, whereas bold font highlights CXCL10 and IL-6 expression.

5′pppRNA-LyoVec (vs LyoVec only)
CD14+CD16−	FC	CD14+CD16+	FC	CD14dimCD16+	FC
CXCL10	12.80	IFNA14	4.16	CCL8	4.43
IFNA14	9.32	IFNA16	4.12	CXCL10	2.18
IFNA16	8.49	IFNB1	3.64	IL1RN	2.04
IFNA2	8.30	CXCL10	3.31	CCR7	2.01
IFNB1	7.64	IL27	3.05	IFNB1	1.93
CCL24	−1.92	CCL24	−1.72	CCL24	−1.50
IL1B	−2.16	IL1A	−1.92	CCL1	−1.61
IL1A	−2.32	IL1B	−1.96	IL3RA	−1.74
CXCL6	−2.55	CXCL5	−2.17	CXCL8	−1.76
CXCL5	−3.53	CCL1	−2.67	IL1B	−2.39
LPS (vs NT)
CD14+CD16−	FC	CD14+CD16+	FC	CD14dimCD16+	FC
IL23A	6.76	IL23A	12.98	IFNG	12.59
CCL22	4.96	IFNG	10.01	IL2RA	6.90
IL24	4.43	CCL20	6.55	IL6	5.08
IL6	4.22	IL24	6.17	IL1B	3.93
CCL3	3.30	IL6	4.77	CCR7	3.66
IL3RA	−3.13	CXCL16	−4.15	IL18BP	−8.19
CCL7	−3.36	CCL13	−5.41	CXCL10	−8.41
CCR1	−4.33	CCL2	−6.19	CXCL16	−9.86
CCL8	−7.99	CCL8	−8.80	CCL8	−10.88
CCL13	−10.45	CXCL10	−9.39	IL13RA1	−14.11
CLO97 (vs NT)
CD14+CD16−	FC	CD14+CD16+	FC	CD14dimCD16+	FC
CCL22	4.34	IFNG	25.98	IFNG	12.69
IL6	3.80	IL18RAP	5.44	IL6	10.39
CXCL2	3.09	IL6	4.41	CCL19	6.08
CCL20	2.58	CXCR4	3.57	CCR7	5.38
CCL3	2.54	IL36G	3.47	IL2RA	4.79
CCR1	−2.78	IL7R	−2.78	IL6R	−3.59
CCL23	−3.00	IL13RA1	−2.93	IL3RA	−3.70
IL18BP	−3.48	IL18BP	−2.96	IL18BP	−4.77
CXCL10	−4.14	CCL13	−3.03	CXCL16	−5.30
CCL13	−4.21	CCL23	−7.18	IL13RA1	−6.88