Table.
Patient No. |
Age/ gender |
Subtype of ATL |
Subtype of AML |
Karyotype of AML | Latent Period (m) |
Preceding Oral VP-16 | Other chemotherapy before AML | Survival (m) |
Refs | |
---|---|---|---|---|---|---|---|---|---|---|
Yes/No | dose/ period (m) |
|||||||||
1 | 49/M | Smoldering | M1 | not evaluable | 0 | No | - | none | 6 | [5], [21] |
2 | 64/M | Acute | M5 | 47,XY,+8 | 17 | No | none | DXR, VP-16, CY, MTX | 18 | [5], [22] |
3 | 37/M | Chronic | M2 | 46,XY,t(9;11)(p22;q23) | 23 | No | - | VCR, CY, DXR, THP-ADM, MCNU, VCM, VP-16, CBDCA | 24 | [5], [23] |
4 | 36/F | Smoldering | M4 | 46, XX, t(15;17)(q22;q21) | 0 | No | - | none | 30+ | [5], [24] |
5 | 74/F | Chronic | M4Eo | 46,XY, inv(16)(p13q22) | 17 | Yes | nr/3 | none | 18 | [5], [13] |
6 | 51/M | Acute | M2 | 46,XY,7q- | 24 | Yes | 20,000 mg/16 | Polypharmacy including high dose VP-16 | nr | [5], [14] |
7 | 81/F | Chronic | M4 | 47,XX,+8,2p-,10p+ | 2 | No | - | none | 29+ | [5] |
8 | 69/M | Acute | M2 | 46,XY,7q-,18p+ | 26 | No | - | CY, DXR, MCNU, THP-ADM, VP-16, CBDCA | 39 | [5] |
9 | 63/F | Lymphoma | M4 | 46,XX,t(8;16)(p11;p13) | 23 | No | - | CY, DXR, VCR, MIT, MTX, VP-16 | 27 | [5] |
10 | 63/F | Acute | M4 | 46,XX,inv(9)(p11q13)c, inv(16)(p13q22) |
23 | Yes | nr/nr | VCR, CY, DXR, MCNU, VCM, VP-16, CBDCA, Ara-C, MTX | 30 | [4] |
11 | 64/M | Acute | M2 | 46,XY,t(8;21)(q22;q22) | 21 | No | - | VCR, CY, DXR, MCNU, VCM, VP-16, CBDCA, Ara-C, MTX, MST-16 | nr | [4] |
12 | 50/F | Lymphoma | M2 | 46, X, t(X;10)(p11.2;p11.2), t(5;12)(q31;p13), inv(9)(p12q13) |
63 | Yes | 10,000 mg/29 | VCR, CY, DXR, MCNU, VCM, VP-16, CBDCA, Ara-C, MTX | 66 | [3] |
Present case | 61/F | Chronic | M2 | 46,XY,t(6;11)(q23,q27) | 47 | Yes | 9,800 mg/41 | none | 58 |
VP-16: etoposide, VCR: vincristine, CY: cyclophosphamide, DXR: doxorubicin, MCNU: ranimustine, VDS: vindesine, CBDCA: carboplatin, Ara-C: cytarabine, MTX: methotrexate: THP-ADM: pirarubicin, MST-16: sobuzoxane, nr: not reported, m: months, refs: references