Table 1.

PPI compounds that inhibited hENGase.^a

No.	Drug Name	Structure	IC50 (μM)
1	Rabeprazole		4.47±0.44
2	Lansoprazole		24.38±1.24
3	Tenatoprazole		~20.0
4	Dexlansoprazole		~25.0
5	Omeprazole		~25.0

^aThe IC₅₀ values of Rabeprazole and Lansoprazole were determined based on 8 dose IC₅₀ curve obtained from three independent experiments; The IC₅₀ values of Dexlansoprazole, Tenatoprazole, and Omeprazole were estimated using four different concentrations from two independent experiments (Fig. S4B).