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. 2017 Aug 8;11:80. doi: 10.1186/s13065-017-0312-2

Table 1.

Antimicrobial and anticancer screening results of synthesized compounds

Compounds No. Minimum inhibitory concentration (MIC = µmol/mL) IC50 (µmol/mL)
Cancer cell line
Bacterial species Fungal species
Gram positive Gram negative
S. aureus
MTCC-3160
B. subtilis
MTCC-441
P. aeruginosa
MTCC-3542
S. enterica
MTCC-1165
E. coli
MTCC-443
C. albicans
MTCC-227
A. niger
MTCC-281
HCT-116
1. 0.72 0.36 1.45 0.72 1.45 1.45 1.45 3.86
2. 0.72 0.72 0.72 0.72 1.45 0.72 1.45 3.86
3. 1.31 0.33 0.66 0.66 1.31 0.66 1.31 3.50
4. 0.75 0.19 0.75 0.75 1.50 0.75 1.50 4.00
5. 0.78 0.78 0.78 1.56 1.56 0.78 1.56 4.16
6. 0.74 0.37 0.74 1.48 1.48 1.48 1.48 3.96
7. 0.67 0.67 1.34 0.67 1.34 1.34 1.34 3.58
8. 0.72 1.45 1.45 0.72 1.45 0.72 1.45 3.86
9. 0.74 0.74 0.74 1.48 1.48 0.74 1.48 1.98
10. 0.74 0.19 0.74 1.48 1.48 0.74 1.48 3.96
11. 0.39 0.39 0.77 0.77 0.77 0.77 1.55 1.52
12. 0.39 0.39 0.77 0.77 1.55 0.77 1.55 0.74
13. 0.17 0.34 0.67 0.67 1.34 0.67 1.34 3.58
14. 1.51 0.75 0.38 1.51 1.51 0.75 1.51 4.02
15. 0.38 0.38 0.75 0.75 0.75 0.75 1.51 2.17
16. 0.17 0.17 0.34 0.67 0.67 0.67 1.34 0.98
17. 0.17 0.34 0.34 0.69 1.37 0.69 1.37 1.22
18. 0.34 0.69 0.69 0.69 1.37 0.34 1.37 0.73
19. 0.75 0.38 0.75 0.75 1.50 0.75 1.50 4.00
20. 0.19 0.38 0.75 0.75 1.50 0.75 1.50 2.16
DMSO 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Cefadroxil 1.72 0.86 1.72 1.72 1.72
Fluconazole 1.02 2.04
5-Fluorouracil 7.67

Std. drugs: cefadroxil—Antibacterial; fluconazole—Antifungal; 5-fluorouracil—Anticancer