Table 2.
Regulation changes in transcription factors in NBS fibroblasts (Ingenuity® Prediction Tool).
| Transcription Regulator | Fold Change (Array data) | Predicted Activation State | Regulation z-score | Number of target molecules |
|---|---|---|---|---|
| TP53 | 1.48 | Activated | 4.32 | 175 |
| CDKN2A | 1.05 | Activated | 3.93 | 46 |
| SMARCA4 | −1.49 | Activated | 3.70 | 34 |
| SMARCE1 | 1.24 | Activated | 2.45 | 6 |
| TCF3 | 2.02 | Activated | 2.39 | 35 |
| Rb (group) | n/a | Activated | 2.26 | 14 |
| GATA1 | −1.09 | Activated | 2.24 | 11 |
| TP63 | −1.00 | Activated | 2.23 | 27 |
| GLI3 | 1.65 | Activated | 2.11 | 4 |
| SMAD7 | −1.63 | Inhibited | −2.13 | 16 |
| SREBF1 | −1.26 | Inhibited | −2.31 | 22 |
| RXRA | 1.08 | Inhibited | −2.46 | 17 |
| SREBF2 | 1.16 | Inhibited | −2.48 | 15 |
| E2F1 | 1.36 | Inhibited | −2.60 | 63 |
| TBX2 | −1.72 | Inhibited | −2.77 | 24 |
| MYCN | −1.07 | Inhibited | −4.41 | 33 |