Table 1.
Cardiac parameters measured by Millar Catheter.
| WT sham (n = 6) | WT TAC (n = 13) | TRPC6 (−/−) sham (n = 6) | TRPC6 (−/−) TAC (n = 11) | |
|---|---|---|---|---|
| Heart Rate (bpm) | 410 ± 6 | 393 ± 6 | 413 ± 5 | 390 ± 5 |
| LVESP (mmHg) | 135 ± 1 | 180 ± 10 ** | 146 ± 4 | 195 ± 6 **,† |
| LVEDP (mmHg) | 0.8 ± 0.5 | 5.4 ± 0.7 ** | 0.7 ± 1.3 | 5.5 ± 1.0 **,† |
| LVdP/dtmax (mmHg/sec) | 10503 ± 531 | 8552 ± 282 ** | 10162 ± 100 | 9023 ± 270 * |
| LVdP/dtmin (mmHg/sec) | 7298 ± 104 | 6598 ± 381 | 7397 ± 161 | 6269 ± 409 |
| Tau (msec) | 12.5 ± 0.3 | 16.0 ± 0.9 | 12.2 ± 0.3 | 19.3 ± 1.4 **,† |
LVESP, left ventricular end systolic pressure; LVEDP, left ventricular end diastolic pressure;
dP/dtmax, maximal rate of pressure development; dP/dtmin, maximal rate of decay of pressure; Tau, monoexponential time constant of relaxation.
*P < 0.05, **P < 0.01 vs WT sham, †P < 0.01 vs TRPC6 (−/−) sham. Results of WT mice were the same as those reported previously17.