Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 8;7:7501. doi: 10.1038/s41598-017-07755-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

DSF screening identified few hit compounds for active VRKs. Heat maps showing DSF screening data for (a) VRK1, (b) VRK2 and (c) AAK1 (included for comparison) versus a 378-compound library of cell-permeable, bioactive kinase inhibitors. The color scheme is the same as in Fig. 1a. Panels indicate rows (x-axis) and lines (y-axis) in a 384-well plate. Numbers show the observed ΔTm shift in degrees Celsius. (d) Bar graph showing ΔTm (°C) for top hit compounds for VRK1 (blue bars) and VRK2 (orange bars). (e) The three compounds used in crystallization. BI-D1870 was used as a racemic mix; the chiral carbon is marked with a star.