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. 2017 Aug 9;8:223. doi: 10.1038/s41467-017-00267-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Fine-mapping of the chromosome 7 locus linked to parasitemia and host mortality. a Plot of peak LOD scores at the chromosome 7 locus, showing the site with peak LOD score (red arrow). b Expanded view of the chromosome 7 locus showing candidate genes and crossover sites for three progenies with genetic recombination within the locus. Genetic markers in a 7.3 kb segment has the highest LOD score defined by crossovers in progenies Cl.13 and Cl.35. c–e Plots of the mean parasitemia with SD from three to five mice infected with three progeny as indicated. f, g Cytokine/chemokine levels (means and SDs) from five mice infected with the parents and three progenies, measured using a mouse magnetic 20-plex kit (Invitrogen) in a Luminex-200 machine according to the manufacturer’s instructions. Two-sided t-test, **P < 0.01; ***P < 0.001