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. 2017 Aug 8;7:7519. doi: 10.1038/s41598-017-07448-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of constructing the CODA network. (a) Associations including both molecular level entities and phenomic level entities are gathered from diverse databases, BioGRID, KEGG pathways, TRANSFAC, GO, PhenoGO, CTD, and EndoNet. All of the associations do not include anatomical contexts at first except for intercellular associations from EndoNet. (b) Anatomical contexts are assigned to associations among molecular level entities by using protein expression data from HPA. For associations including phenomic level entities, anatomical contexts are added to the associations using MeSH of their reference literature. Intercellular associations have anatomical context ab initio. (c) As a result, constructed CODA network consists of not only organ/cell type specific networks but also intercellular associations. Diverse associations among molecular level entities and phenomic level entities with anatomical context are contained in CODA network.