Table 3.
Significant miRNA target genes in TCGA
| miRNA | Significant target genes (P ≤ 0.05 and the log2 [fold change]) |
|---|---|
| miR‐100‐5p | CDK6, EIF5A, PSMA5, BAZ1B, LSM5, ATP1B3, RNFT1, CLCN5, COL4A1, RAB15, NKX3‐1, RB1, DDX21, EWSR1, YWHAE, NMT1, TTC30A, LIN28B, AP1AR, ABCB6, GNA13, GRB2, WDR4, ORC5, CCZ1B, CTDSPL2 |
| miR‐133b | SMARCD1, MET, ZNF131, FOXC1, COL5A3, SLC39A1 |
| miR‐155‐5p | CAB39L, METTL7A, INA, C3orf18, TTC37, PGRMC2, MITF, CD36, ATPAF1, PCDH9, MUT, TBC1D14, GABARAPL1, PDCD4, KIAA0430, KRCC1, ANAPC16, SETMAR, CDH2, EEF1A2, ZNF652, ERGIC1, RAB11FIP2, SAP30L, ZIC3, PHF17, GPT2, AGTR1, SKIV2L2, GHITM, DMD, ATP6V1H, PNPLA4, STIM1, NOVA1, TAB 2, JUN, SACM1L, CBR4, PCYOX1, ZNF493, GPM6B, OXCT1, AKR1C3, PALLD, CFL2, CAT, HSD17B12, IPO8, LTN1, PAK7, RIOK2, EIF3L, MPP2, UAP1, CYP2U1, FLNA, KANK2, TMBIM6, PIK3R1, MRS2, FOXO3, FGF2, SLC9A3R2, MPP5, MARCH2, PACSIN2, PRKAR2A, ARL6IP5, OSBPL9, ALDH1A2, PEBP1, ALDH3A2, NSA2, SNAP29, AGL, DDX17, ECI1, FAR1, AP1G1, INTS6, CRAT, MAN1A2, GLIPR2, PSIP1, XPC, MLH1, NR3C1, WRB, TNKS1BP1, RBPJ, TMED7‐TICAM2, CLIC4, SMAD4, SOX1, CSNK1A1, C16orf62, UGDH, SPECC1, NCKAP1, LONP2, TSHZ3, ZNF561, TRAK1, CTNNA1, RAB27B, ADH5, RAB6C, CLGN, CHD9, MEF2A, SNTB2, PKIA, LARS |
| miR‐21‐5p | FOXN3, FBXL17, LONRF2, CPEB3, LIFR, EPM2A, PAIP2B, PGRMC2, TGFBR3, LYRM7, LIMCH1, PDCD4, SASH1, ECI2, GPD1L, FBXL5, ARHGAP24, PURA, NFIA, FMOD, DCAF8, BTG2, CCNG1, ACAT1, KLF9, RNF11, UTRN, NBEA, ZBTB47, RAB11FIP2, DOCK3, SLAIN2, PRKAB2, FBXO3, ELAVL4, C20orf194, ISCU, PPM1L, PHF17, NEK1, RECK, COBLL1, MOAP1, GNAQ, DMD, ZBTB20, PDGFD, DDR2, FKBP5, PBX1, BDH2, FNBP1, MYO9A, TACC1, TIMP3, USP47, CYBRD1, MEGF9, BOC, SACM1L, DYNC1LI2, ATRX, FILIP1L, GOLGA4, ZBTB8A, TPRG1L, PALLD, TCF21, MYEF2, ZNF667, SOD3, PPAP2A, RHOB, WNK3, MKNK2, RUFY3, CALD1, TMX4, PRICKLE2, WFS1, SERPINI1, TUBGCP5, PHACTR2, SLMAP, PIK3R1, ARID4A, FERMT2, FAM63B, RNF38, IPP, SATB1, PER3, WDR47, TGFBR2, WDR7, PIGN, KLHL3, TSC1, MPP5, MON2, SEC63, CDS2, ARHGEF12, REV3L, SYBU, APPL1, AGGF1, JMY, BTBD3, WNK1, SESN1, DAAM1, TMEM56, PRKCE, SERAC1, ZYG11B, APOLD1, SPG11, FIGN, ANKRD46, PTGFR, PKD2, TM9SF3, MPDZ, RXRA, PTEN, CEP104, ITSN2, EIF4EBP2, CLOCK, ATP2B4, DCAF10, HECTD1, EIF2AK3, ZADH2, CSNK1A1, ESYT2, OSR1, CAPN2, DOCK8, NR2C2, MYCBP2, TEK, PTX3, VCL, ZRANB1, CYP4V2, FAM46A, TSHZ3, GPR64, SREK1, NIN, TPM1, PPP1R3B, EIF4A2, ARIH2, RAB6C, MLXIP, MTMR12, ABCD3, PPARA, MEF2A, NEK7, TOPORS, LARS |
| miR‐223‐3p | SLC2A4, ERO1LB, NFIA, FBXO8, RHOB, NFIX, ZFHX3, FBXW7, EPB41L3 |
The targeted genes participating in pathways (KEGG and Panther enrichment pathways) are tested in the TCGA database, and then screening with the rules for hsa‐miR‐100‐5p and hsa‐miR‐133b: P ≤ 0.05, and log2 (fold change) >0; hsa‐miR‐155‐5p, hsa‐miR‐21‐5p and hsa‐miR‐223‐3p: P ≤ 0.05, and log2 (fold change) <0.