Table 2.
Risk of head and neck cancer overall and for subsites in tobacco smokers and alcohol drinkers within strata of endogenous and exogenous hormones variables, INHANCE Consortium
| Overall head and neck | Oral cavity | Oropharynx | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (E/E–) | Controls (E/E–) | OR (95% CI) | P interact | Cases (E/E–) | Controls (E/E–) | OR (95% CI) | P interact | Cases (E/E–) | Controls (E/E–) | OR (95% CI) | P interact | |
| Ever used HRT (ever vs. never) | ||||||||||||
| Alcohol drinking status | 0.01 | 0.002 | 0.75 | |||||||||
| Never | 133/191 | 415/638 | 0.50 (0.25–1.00) | 44/95 | 415/638 | 0.44 (0.15–1.26) | 10/45 | 415/638 | 0.47 (0.15–1.48) | |||
| Ever | 219/427 | 330/685 | 0.61 (0.36–1.05) | 92/167 | 330/685 | 0.70 (0.36–1.37) | 42/127 | 330/685 | 0.48 (0.29–0.80) | |||
| Tobacco smoking status | 0.06 | 0.31 | 0.02 | |||||||||
| Never | 98/199 | 492/864 | 0.49 (0.23–1.04) | 41/104 | 492/864 | 1.04 (0.63–1.73) | 11/37 | 492/864 | 0.70 (0.25–2.02) | |||
| Ever | 267/426 | 283/479 | 0.50 (0.31–0.82) | 97/161 | 283/479 | 0.58 (0.39–0.85) | 41/137 | 283/479 | 0.45 (0.27–0.75) | |||
| Ever used OC (ever vs. never) | ||||||||||||
| Alcohol drinking status | 0.02 | 0.61 | 0.14 | |||||||||
| Never | 21/75 | 97/532 | 0.74 (0.34–1.61) | 6/30 | 97/532 | 0.53 (0.15–1.90) | 4/20 | 97/532 | 0.35 (0.07–1.88) | |||
| Ever | 63/273 | 226/798 | 0.53 (0.34–0.83) | 23/76 | 226/798 | 0.65 (0.32–1.32) | 18/98 | 226/798 | 0.54 (0.26–1.10) | |||
| Tobacco smoking status | 0.21 | 0.60 | 0.01 | |||||||||
| Never | 24/98 | 184/991 | 0.82 (0.46–1.47) | 8/41 | 184/991 | 0.56 (0.22–1.45) | 8/21 | 184/991 | 1.20 (0.43–3.38) | |||
| Ever | 63/249 | 147/378 | 0.63 (0.39–1.01) | 23/68 | 147/378 | 0.83 (0.37–1.82) | 13/62 | 147/378 | 0.39 (0.17–0.91) | |||
| Ever given birth (ever vs. never) | ||||||||||||
| Alcohol drinking status | 0.28 | 0.45 | 0.08 | |||||||||
| Never | 103/41 | 565/160 | 0.89 (0.61–1.30) | 42/15 | 565/160 | 0.79 (0.44–1.40) | 22/9 | 565/160 | 0.85 (0.29–2.50) | |||
| Ever | 287/117 | 990/191 | 0.50 (0.29–0.84) | 92/45 | 990/191 | 0.78 (0.35–1.72) | 67/33 | 990/191 | 0.68 (0.36–1.25) | |||
| Tobacco smoking status | <0.001 | 0.12 | 0.06 | |||||||||
| Never | 104/42 | 1074/217 | 0.80 (0.50–1.27) | 42/15 | 1074/217 | 0.81 (0.42–1.56) | 30/5 | 1,074/217 | 1.39 (0.46–4.20) | |||
| Ever | 278/111 | 520/139 | 0.68 (0.46–1.00) | 89/43 | 520/139 | 0.77 (0.42–1.43) | 59/39 | 520/139 | 0.46 (0.25–0.88) | |||
Models adjusted for study (and center for multicenter studies), age (<40, 40–44, 45–49, 50–54, 55–59, 60–64, 65–69, 70–74, 75+ years), education level (≤high school, > high school), amount of alcohol drinking (nondrinker, 0.1–0.9, 1.0–2.9, 3.0–4.9, and 5.0+ drinks/day), body mass index (normal weight, underweight, overweight, and obese), and cumulative tobacco smoking (never smoker, smoked 0–10.0, 10.1–20.0, 20.1–30.0, 30.1–40.0, 40.1–50.0, 50.0+ pack‐years).
E, exposed; E–, unexposed; HRT, hormone replacement therapy; OC, oral contraceptives; OR, Odds ratios.