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. 2017 Aug 8;7:7589. doi: 10.1038/s41598-017-08162-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Genetic arrangement of the streptococcal invasive locus in the CC20-isolates. The sil-locus in the CC20 isolates has a transposase, IS1548, inserted into the silB-gene. silB encodes a sensory kinase activating the putative DNA response regulator encoded by silA. This leads to increased transcription of the virulence attenuating pheromone encoded by silCR, and suppression of the virulence associated silC-gene. The SilC-peptide is exported from the cell by the transporter-proteins SilD and SilE. Scale indicates nucleotide position. This disrupted sil-locus is deposited in GenBank under the accession code KY807567.