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. 2017 Aug 8;7:7533. doi: 10.1038/s41598-017-07757-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RNA-seq analysis on HepG2 cells cultured with and without PenStrep. (A) Shown in the top left is a heatmap depicting relative expression levels for all 209 differentially expressed genes across all three replicates per treatment. To the right of each cluster, the top gene ontology terms as determined by DAVID v6.8²⁴ are shown. (B) PenStrep DE genes canonical pathways and upstream regulators with the top five highest binomial fold enrichment values and most significant p-values as determined by IPA. (C) IPA network analysis for gentamicin, one of the top most significant upstream regulators for PenStrep DE genes. This network is drawn based on calculated z-scores for published gene expression patterns under gentamicin as determined by IPA.