Table 1.
RNA-Seq data for genes known to be selectively expressed by Tas1r3+ and type III taste cells based on evidence from the literature. “Marked cell type” = a cell type where the gene is reported to be expressed. “Log2FC” = fold change (Tas1r3+ vs. type III cells) in log2 scale. FDR = p values adjusted for multiple comparisons using false discovery rate (the Benjamini-Hochberg procedure implemented in the DESeq2 package).
| Gene symbol | Gene name | Marked cell type | Average counts | Log2FC | FDR | |
|---|---|---|---|---|---|---|
| Tas1r3+ | Type III | |||||
| Plcb2 | phospholipase C, beta 2 | Tas1r3+ | 52005 | 2.2 | −14.4 | 1.10E-103 |
| Tas1r2 | taste receptor, type 1, member 2 | Tas1r3+ | 3103.2 | 0.1 | −14.8 | 1.10E-26 |
| Tas1r3 | taste receptor, type 1, member 3 | Tas1r3+ | 6619.5 | 48.4 | −6.7 | 1.58E-05 |
| Tas1r1 | taste receptor, type 1, member 1 | Tas1r3+ | 1804.5 | 14.8 | −6.4 | 7.14E-04 |
| Trpm5 | transient receptor potential cation channel, subfamily M, member 5 | Tas1r3+ | 22979 | 1.5 | −13.7 | 2.33E-62 |
| P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7 | Tas1r3+ | 1624.7 | 30.8 | −5.3 | 2.73E-03 |
| Gna14 | guanine nucleotide binding protein, alpha 14 | Tas1r3+ | 22803 | 26.9 | −9.1 | 1.37E-08 |
| Gng13 | guanine nucleotide binding protein, gamma 13 | Tas1r3+ | 681.5 | 0.08 | −12.3 | 8.42E-21 |
| Chgb | chromogranin B | Type III | 1.5 | 8288.3 | 12.1 | 8.38E-38 |
| Chga | chromogranin A | Type III | 4.7 | 8001.3 | 10.3 | 8.09E-21 |
| Ncam1 | neural cell adhesion molecule 1 | Type III | 30.4 | 16476.9 | 8.9 | 1.15E-26 |
| Gad1 | glutamate decarboxylase 1 | Type III | 2.5 | 33978.7 | 13.5 | 1.90E-64 |
| Car4 | carbonic anhydrase 4 | Type III | 11.3 | 9307 | 9.2 | 1.57E-10 |
| Pkd2l1 | polycystic kidney disease 2-like 1 | Type III | 4.5 | 28791.2 | 12.6 | 7.70E-158 |
| Pkd1l3 | polycystic kidney disease 1 like 3 | Type III | 23 | 24051.7 | 9.8 | 4.24E-30 |
| Snap25 | synaptosomal-associated protein 25 | Type III | 70.5 | 73176.5 | 9.9 | 1.51E-50 |
| Cacna2d1 | calcium channel, voltage-dependent, alpha2/delta subunit 1 | Type III | 11.5 | 26660.5 | 11.0 | 6.09E-42 |