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. 2017 Aug 8;7:7608. doi: 10.1038/s41598-017-07527-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evolution of the temporal behavior of the CSTC pathway in response to changes in global excitation (c _e) and inhibition (c _i). Each curve represents the temporal evolution in the activity of the cortex (blue), striatum (cyan) and thalamus (green). The insets show the values of c _e and c _i used in each set of simulations (c _e = 8, 15, 20, 30 and c _i = 10, 20, 40). Excitation increases from left to right in each row. Inhibition increases from bottom to top in each column. Other parameters are fixed as follows: τ _e = 4, b _e = 1.2, τ _i = 2, b _i = 1, P = 1.