Table III.
Association between risk factors and rs2276724 in HBV-related HCC patients.
| Variables | TT | CT+CC | OR (95% CI) | P-value |
|---|---|---|---|---|
| Tumor size (cm) | ||||
| ≤5 | 98 | 70 | 1 | |
| >5 | 147 | 100 | 0.952 (0.640–1.418) | 0.810 |
| Tumor number | ||||
| Single | 176 | 126 | 1 | |
| Multiple | 69 | 44 | 0.891 (0.573–1.386) | 0.608 |
| Child-Pugh score | ||||
| A | 211 | 145 | 1 | |
| B | 34 | 25 | 1.070 (0.612–1.869) | 0.812 |
| BCLC stage | ||||
| A | 136 | 100 | 1 | |
| B | 43 | 25 | 0.791 (0.453–1.379) | 0.408 |
| C | 66 | 45 | 0.927 (0.586–1.467) | 0.747 |
| Radical resectiona | ||||
| Yes | 133 | 98 | 1 | |
| None | 103 | 69 | 0.909 (0.609–1.358) | 0.642 |
| AFP levelb | ||||
| <400 | 122 | 88 | 1 | |
| ≥400 | 109 | 66 | 0.839 (0.557–1.266) | 0.403 |
| Regional invasion | ||||
| Absence | 209 | 144 | 1 | |
| Presence | 36 | 26 | 1.048 (0.606–1.812) | 0.866 |
| PVTT | ||||
| No | 199 | 143 | 1 | |
| Yes | 46 | 27 | 0.817 (0.485–1.376) | 0.447 |
| Pathological diagnosisc | ||||
| Well differentiated | 13 | 11 | 1 | |
| Moderately differentiated | 198 | 143 | 0.854 (0.372–1.960) | 0.709 |
| Poorly differentiated | 7 | 4 | 0.675 (0.156–2.930) | 0.600 |
a
Information regarding radical resection was unavailable for 12 patients
b
information regarding pathological diagnosis was unavailable for 39 patients
c
information regarding AFP level was unavailable for 30 patients. HBV, hepatitis B virus; HCC, hepatocellular carcinoma; OR, odds ratio; CI, confidence interval; BCLC stage, Barcelona Clinic Liver Cancer stage; PVTT, portal vein tumor thrombus; AFP, α-fetoprotein