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. 2017 Aug 9;2(4):e00167-17. doi: 10.1128/mSphere.00167-17

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Copyright © 2017 Weil et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Fluconazole resistance profiles during evolution. (A) During evolution with fluconazole (FLZ), control strain TO (3.2% natural mistranslation; blue line) and hypermistranslating strain T1 (22.5% leucine misincorporation; red line) showed increased resistance to the drug over time yet revealed marked differences in the speed of resistance acquisition. Both strains evolved without (w/o) the drug (green and gray lines) did not show increased resistance. (B) E tests after 10 days of evolution. Hypermistranslating strain T1 rapidly adapted to the drug and showed complete resistance to fluconazole, while WT strain T0 was still sensitive.