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. 2016 May 10;17(4):386–392. doi: 10.1038/tpj.2016.34

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Calculation of clinical validity and potential population impact measures from 2 × 2 contingency tables reporting adverse event by genetic variant subgroups. Contingency tables can be constructed using empirical data or using hypothetical data calculated from summary statistics and association measures, such as odds ratios derived from observational studies with a case–control design in combination with the frequencies of the genetic variant and the adverse event (see Supplementary Information).