Fig. 2.

Progression free survival curves from the most recent studies on advanced melanoma patients with brain metastases. This figure shows the PFS curves from two of the most recent clinical studies in advanced melanoma patients with brain metastases (BM). The curves come from the checkmate 204 study, a phase 2 study with the combination of ipilimumab and nivolumab in advanced melanoma patients with BM [20], and from combi-MB, a phase 2 study with the combination of dabrafenib/trametinib that both reported overall PFS in patients without previous treatment for brain metastases [22]. The intent of this figure is not to directly compare results from different trials, but highlight the possibility of immunotherapy to reach, even in this group of patients with a difficult disease to treat, long-term benefit (the high and flattening tail of the curve)