Table 3.
Univariate and multiple linear regression models for serum NGAL (A) and MMP-9/NGAL (B, log-transformed) concentrations in the total cohort
| Univariate models | Multiple model | |||
|---|---|---|---|---|
| β ± SEa | p | β ± SEa | p | |
| (A) | ||||
| BMI | −0.21 ± 1.01 | 0.832 | 0.42 ± 0.67 | 0.532 |
| Creatinine (rank-transformed) | 0.32 ± 0.10 | 0.002 | 0.14 ± 0.07 | 0.056 |
| Neutrophils (log-transformed) | 35.9 ± 12.1 | 0.003 | 4.4 ± 8.6 | 0.609 |
| Plaque ultrasound | <0.0001 | 0.004 | ||
| “calcified/hard”vs. “soft” | −59.3 ± 7.3 | −18.4 ± 7.6 | ||
| “mixed” vs. “soft” | −55.5 ± 9.2 | −26.1 ± 8.0 | ||
| Histological classification | <0.0001 | <0.0001 | ||
| Type VI vs. type V | 56.6 ± 7.5 | 33.0 ± 7.3 | ||
| Type VII vs. type V | −21.7 ± 7.4 | −18.8 ± 6.8 | ||
| Symptomatic (yes vs. no) | 27.8 ± 8.0 | 0.0007 | 12.9 ± 5.6 | 0.023 |
| T2DM (yes vs. no) | 50.8 ± 6.9 | <0.0001 | 29.1 ± 6.0 | <0.0001 |
| (B) | ||||
| BMI | 0.03 ± 0.02 | 0.086 | 0.03 ± 0.02 | 0.100 |
| Creatinine (rank-transformed) | −0.001 ± 0.0020 | 0.517 | −0.002 ± 0.002 | 0.391 |
| Neutrophils (log-transformed) | 0.89 ± 0.20 | <0.0001 | 0.57 ± 0.22 | 0.010 |
| Plaque ultrasound | 0.0004 | 0.257 | ||
| “calcified/hard”vs. “soft” | −0.59 ± 0.15 | −0.26 ± 0.19 | ||
| “mixed” vs. “soft” | −0.49 ± 0.19 | −0.31 ± 0.20 | ||
| Histological classification | 0.004 | 0.196 | ||
| Type VI vs. type V | 0.45 ± 0.17 | 0.27 ± 0.19 | ||
| Type VII vs. type V | −0.13 ± 0.17 | −0.12 ± 0.17 | ||
| Symptomatic (yes vs. no) | −0.08 ± 0.15 | 0.602 | −0.17 ± 0.14 | 0.239 |
| T2DM (yes vs. no) | 0.34 ± 0.14 | 0.017 | 0.04 ± 0.15 | 0.801 |
aRegression parameter (β) ± standard error (SE)