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. 2017 Aug 8;18:588. doi: 10.1186/s12864-017-4000-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Average fraction of variants within charge clusters and their corresponding background sequences. The variant fractions were calculated according to the formula in the Methods section (The recovery of the variant data) within negative (a) and positive (b) charge clusters and their corresponding genes, full mRNAs and intron + exon sequences. Variant fractions within clusters of both charges (a and b) are in average bigger than those within their genes, full mRNAs and exon + intron sequences