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. 2017 May 10;35(23):2656–2665. doi: 10.1200/JCO.2016.71.0285

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Fig 4. — (A) Change in severity of fatigue symptoms from baseline to month 15 follow-up in the cognitive behavioral therapy for insomnia (CBT-I) and Tai Chi Chih (TCC) treatment groups. Higher scores on the Multidimensional Fatigue Symptom Inventory indicate more fatigue severity. Values are means, and bars indicate standard error of measurement. Measurements were obtained at baseline 1 (BL1), baseline 2 (BL2), and months 2, 3, 6, and 15. The numbers of participants evaluated at each time point for each group are as follows: BL1: TCC, n = 45; CBT-I, n = 45; BL2: TCC, n = 45; CBT-I, n = 45; month 2: TCC, n = 38; CBT-I, n = 44; month 3: TCC, n = 38; CBT-I, n = 42; month 6: TCC, n = 35; CBT-I, n = 40; and month 15: TCC, n = 33; CBT-I, n = 40. Shaded area indicates period of exposure intervention after baseline assessment. Comparisons between BL1 and BL2 were not significant (t_374.9 = 1.8; P = .20). Significant pairwise comparisons were found between BL2 and months 2, 3, 6, and 15 (all P < .001). No significant differences were found between CBT-I and TCC at BL1, BL2, months 2, 3, 6, and 15 (all P > .10). (B) Change in clinician-rated severity of depressive symptoms from baseline to month 15 follow-up in the CBT-I and TCC intervention groups. Higher scores on the Inventory of Depressive Symptomology indicate worse depressive symptoms. Values are means, and bars indicate standard error or measurement. Measurements were obtained at BL1, BL2, and months 2, 3, 6, and 15. The numbers of participants evaluated at each time point for each group are as follows: BL1: TCC, n = 45; CBT-I, n = 45; BL2: TCC, n = 45; CBT-I, n = 45; month 2: TCC, n = 38; CBT-I, n = 44; month 3: TCC, n = 38; CBT-I, n = 42; month 6: TCC, n = 35; CBT-I, n = 40; and month 15: TCC, n = 33; CBT-I, n = 40. Shaded area indicates period of administration of intervention after baseline assessment. Comparisons between BL1 and B2 were not significant (t_371.5 = 0.7; P = .34). Significant pairwise comparisons were found between BL2 and months 2, 3, 6, and 15 (all P < .01). No significant differences were found between CBT-I and TCC at BL1, BL2, months 2, 3, 6 and 15 (all P > .10).