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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Dev Biol. 2017 Jun 7;428(1):188–203. doi: 10.1016/j.ydbio.2017.06.003

Fig. 2.

Fig. 2

Postnatal hair follicle refinement is independent of Vangl2 and Fz6. (A–C) Wild type control (A), Vangl2 cKO, (B) and Fz6 KO (C) dorsal skins at P2. Hair follicles are pseudo-colored according to their angle using Orientation J. Green-blue represents hair follicles oriented closest to the AP axis ~ 0° to +/− 45°. Pink-purple ~ −45° to −90°. Orange-yellow ~ +45° to +90°. The boxed regions are shown zoomed in on the right. Quantification of hair follicle angles plotted relative to their position along the anterior-posterior axis is shown below. Each dot represents the average orientation of follicles within one square window, tiled across the backskin. See Methods. Each color shade represents data from one animal. For control n=6, Vangl2 cKO n=5, and Fz6 KO n=3 animals. (D–F) The same analysis was carried out at P7. For control n=4, Vangl2 cKO n=5, and Fz6 KO n=3. Note that the disordered hair pattern at P2 is aligned with the anterior-posterior axis by P7. Scale bar, 1 mm.