Figure 5.

Inflammatory cytokine secretion by keratinocyte-fibroblast cocultures is blocked by neutralizing antibodies to IL-1α. IL-6, CCL2, CXCL1, and CXCL8 secretion by skin and gingiva keratinocyte-fibroblast cocultures after 24-hour exposure to Hst1 and LL-37, together with either neutralizing antibodies to IL-1α (white bars) or isotype control (black bars). Each bar represents the mean ± standard error mean of 3 independent experiments each performed in duplicate. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.005.