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Transfection of HMGCS2 reduces the levels of acetylated MnSOD (K122) and 4-HNE. (a) 4-HNE levels in transfected cells treated with 0.1 mM H2O2. (b) Western blot analysis of acetylated MnSOD (K122) and total MnSOD and the ratio of acetylated MnSOD/MnSOD. (c, d, e) HMGCS2, SIRT3, and Nampt protein expression in transfected HEK293 cells treated with GTPs. The data are represented as the mean ± SD (n = 4–6); ∗P < 0.05.
