Table 2. Phenotypic characteristics of Mouse regulatory B-cell subsets.

Breg Type	Phenotype	Key feature	Reference
B10	CD5+CD1dhi	Found in mice spleen produce IL-10, and suppress effector CD4+ T-cell and monocytes function	23, 26
MZ	CD19+CD21hiCD23-CD24hiIgMhiIgDlo CD1dhi	Found in spleen, produce IL-10, induce Treg cells and suppress effector CD8+ and CD4+ T cells	38, 39
T2-MZP cells	CD19+CD21hiCD23hi	Produce IL-10, found in spleen, induce Treg cells and suppress effector CD8+ and CD4+ T cells	18, 37, 40
Tim-1+B cells	Tim-1+CD19+	Produce IL-10, found in mice spleen and suppress effector CD4+ T cells	41
Plasma cells	CD138+IgM+CD1dhi CXCR4+MHC-11lo	Produce IL-10 and IL-35, found in spleen suppress NK cells, neutrophils and effector CD4+ T cells	42
Plasmablast	CD138+CD44hi	Produce IL-10, found in dLNs and suppress DCs and effector CD4+ T cells	43
GIFT-15 B cells	B220+CD21+CD22+CD23+CD24+CD1d+ CD138+ IgD+IgM+	GMCSF and IL-15 induced IL-10 secreting Bregs that suppressed IFN-y responses	44
PD-L1hi B cells	PD-L1hi CD19+B220+	Regulated humoral responses by CD4+CXCR5+PD-1+ follicular helper T cells	30

Abbreviations: Breg, regulatory B cell; DC, dendritic cell; dLN, draining lymph node; MHC, major histocompatibility complex; MZ, marginal zone; NK, natural killer; T2-MZP, transitional 2 marginal zone precursor.