Table 2. Phenotypic characteristics of Mouse regulatory B-cell subsets.
Breg Type | Phenotype | Key feature | Reference |
---|---|---|---|
B10 | CD5+CD1dhi | Found in mice spleen produce IL-10, and suppress effector CD4+ T-cell and monocytes function | 23, 26 |
MZ | CD19+CD21hiCD23-CD24hiIgMhiIgDlo CD1dhi | Found in spleen, produce IL-10, induce Treg cells and suppress effector CD8+ and CD4+ T cells | 38, 39 |
T2-MZP cells | CD19+CD21hiCD23hi | Produce IL-10, found in spleen, induce Treg cells and suppress effector CD8+ and CD4+ T cells | 18, 37, 40 |
Tim-1+B cells | Tim-1+CD19+ | Produce IL-10, found in mice spleen and suppress effector CD4+ T cells | 41 |
Plasma cells | CD138+IgM+CD1dhi CXCR4+MHC-11lo | Produce IL-10 and IL-35, found in spleen suppress NK cells, neutrophils and effector CD4+ T cells | 42 |
Plasmablast | CD138+CD44hi | Produce IL-10, found in dLNs and suppress DCs and effector CD4+ T cells | 43 |
GIFT-15 B cells | B220+CD21+CD22+CD23+CD24+CD1d+ CD138+ IgD+IgM+ | GMCSF and IL-15 induced IL-10 secreting Bregs that suppressed IFN-y responses | 44 |
PD-L1hi B cells | PD-L1hi CD19+B220+ | Regulated humoral responses by CD4+CXCR5+PD-1+ follicular helper T cells | 30 |
Abbreviations: Breg, regulatory B cell; DC, dendritic cell; dLN, draining lymph node; MHC, major histocompatibility complex; MZ, marginal zone; NK, natural killer; T2-MZP, transitional 2 marginal zone precursor.