Table 3. Phenotypic characteristics of Human regulatory B-cell subsets.
Breg Type | Phenotype | Key feature | Ascribed function |
---|---|---|---|
B10 | CD24hiCD27+ | Found in human blood, produce IL-10, and suppress effector CD4+ T cells and monocyte function | 23, 26, 55 |
Transitional B cells | CD19+CD24hiCD38hi | Produce IL-10, found in blood and at site of inflammation, induce Treg cells, suppress Th1 and Th17 cells, suppress virus specific CD8+ T-cell responses | 25, 27, 56, 57 |
Memory B cells | CD19+CD27+IgM+ | Produce IL-10 and found in human blood. Suppress CD4+ T-cell proliferation and effector function | 27 |
Plasmablast | CD19+CD38hiCD24hi CD27int | Produce IL-10, found in human blood and suppress DCs and effector CD4+ T cells | 43, 58 |
GrB+ B cells | CD19+CD38+CD1dhi IgM+CD147+ | IL-21 induced Granzyme B-expressing B cells suppressed T-cell proliferation | 59 |
Br1 cells | CD19+CD25hiCD71hi CD73lo | Found in blood and produce IL-10 and IgG4 | 60 |
Abbreviations: Br1, B regulatory 1; DC, dendritic cell; IgG4, immunoglobulin G4; NK, natural killer.