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. Author manuscript; available in PMC: 2018 Jun 30.
Published in final edited form as: Curr Opin Virol. 2017 Jun 30;24:124–131. doi: 10.1016/j.coviro.2017.06.003

Figure 1.

Figure 1

Schematic representation of the possible roles of AAVR in the AAV life cycle - (i) AAV binds to HSPG, allowing subsequent interaction with AAVR at the cell surface, which facilitates entry into the endosomal network; (ii) AAVR interacts with AAV in the endosomal system and facilitates trafficking to the trans-Golgi. (iii) Once in the trans-Golgi network, AAVR facilitates AAV escape into the cytoplasm.