Table 1. Demographic characteristics and clinical outcomes of the cohort.
| Parameter | Median (IQR), mean ± SD, or n (%) |
|---|---|
| Age | 3.5 (IQR 0.75–14.2) |
| Age groups | |
| < 1 yr | 18 (35%) |
| 1–2 years | 7 (13.7%) |
| 2–8 years | 10 (19.6%) |
| 8 years | 16 (31.4%) |
| Gender, female | 36 (71%) |
| Admission weight, kg | 13.8 (9.6–49.8) |
| Mechanical ventilation, n (%) | 49 (96.1%) |
| Length of mechanical ventilation, days | 17 (7–29) |
| Inotrope use, n(%) | 48 (94%) |
| Length of hospital stay, days | 40 (25–97) |
| Length of PICU stay, days | 27 (14–55) |
| Primary liver disease | 30 (61.2%) |
| Etiology for liver failure | |
| Biliary atresia | 19 (37.3%) |
| Metabolic | 5 (9.8%) |
| HLH | 2 (3.9%0 |
| Shock liver | 3 (5.9%) |
| Hepatitis, NOS | 4 (7.8%) |
| Autoimmune | 4 (7.8%) |
| Multiple organ failure | 2 (3.9%) |
| Other | 12 (23.5%) |
| Peak total bilirubin, mg/dL | 22.6±18.7 |
| Peak conjugated bilirubin, mg/dL | 18.1±14.4 |
| Nadir albumin, g/dL | 2.1 (1.8–2.2) |
| Peak INR | 4.2 (2.6–6.3) |
| Nadir serum sodium, mEq/L | 132 (127–135) |
| Platelets at CRRT start (103/μL) | 81.8 ± 53.6 |
| Total calcium, mmol/L | 2.6±0.5 |
| Ionized calcium, mmol/L | 1.2±0.2 |
| Peak lactate | 6.4 (5.2–12) |
| Hospital mortality | 29 (56.9%) |
| Orthotopic liver transplant, n (%) | 26 (51%) |
| Evaluated for OLT | 35 (68.6%) |
| Listed for OLT | 33/35 (94.3%) |
| Bridged to OLT on CRRT, n (%) | 10 (19.6%) |
PICU, pediatric intensive care unit; HLH, hemophagocytic lymphohistiocytosis; NOS, not otherwise specified; INR, international normalized ratio; CRRT, continuous renal replacement therapy; OLT, orthotopic liver transplantation.