Fig 2. Convergent neighboring gene network shared by AIDS, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and age macular degeneration: Convergent gene networks are primarily the shared molecular pathways between networks of genes of two or more different diseases.

In our case, the term neighboring is added because networks of individual diseases represent neighboring interactants of at-risk genes. The developed network revealed the involvement of immunological pathways as retrieved by geneMANIA with P< 10⁻¹⁰. The network was developed using the 10 common genes (black dots) found via Venn analysis. Few of these common genes are also seen in other neuro-disorders: Amyotrophic Lateral Sclerosis (AKT1, EGFR, & IKBKB), Glaucoma (AKT1 & EGFR), Vascular Dementia (AKT1 & IKBKB), and Migraine and Restless leg syndrome (AKT1). Narcolepsy, Creutzfeldt-Jakob disease, and Autism-autism spectrum did not share genes with these common gene sets suggesting least chance of these symptoms during neuroAIDS. Genes in grey dots represent networking genes retrieved by geneMANIA where smaller to higher grey circle sizes represents weaker to the stronger degree of connectivity/associations between two proteins. Colored connecting line between two genes/proteins indicates interactions between them (red-physical; orange-predicated, and green-genetic) and blue lines are part of pathways. Pathways involved in this gene circuit, together with the pathways involved in Fig 4, suggests commonalities in the immunological basis of different neuropathogenesis.