Fig 8. Proposed signaling mechanism for the effects of 4'-HW on LPS-induced inflammation in RAW 264.7 macrophages.
4'-HW exerts its anti-inflammatory activity on RAW 264.7 macrophages by inhibiting ROS production, TAK1/IKK/NF-κB signaling pathway and reducing the phosphorylation of NF-κB, MAPKs and PI3/Akt signaling pathways.