Table 1.
Ribosomal protein promoters Quality of the TATA Box Motifs, the Number of Transcription Factor-Binding Sites and the Location of AUG Codons.
| RP GENE | TATA Quality | % H/M identity in 300 bp ‡ | GABP (5' of tsp) | Sp1 (5' of tsp) | YY1 (3' of tsp) | OTHER (5' of tsp) | AUG † | ||||
| Hs | Mm | H-M | H | H-M | H | H-M | H | ||||
| SA | + | + | 58 | 1 | 2 | 1 | ATF, CREB | E2 | |||
| S2 | + | + | 54 | 1 | 1 | E2 | |||||
| S3 | + | + | 60 | 1 | 1 | 1 | E1 | ||||
| S3a | – | – | 75 | 2 | 1 | AP1 | E1 | ||||
| S4 | +/– | +/– | 70 | 1 | 1 | 1 | E1e | ||||
| S5 | +/– | + | 62 | 1 | E2 | ||||||
| S6 | – | – | 56 | 3 * | 1 | 1 | Box A * | E1 | |||
| S7 | +/– | + | 56 | 4 | 2 | Box A | E2 | ||||
| S8 | +/– | +/– | 60 | 1 | E1e | ||||||
| S9 | + | + | 50 | 1 | 1 | ATF, CREB, AP1 | E2 | ||||
| S10 | – | – | 64 | 1 | 1 | 1 | 1 | Nrf1 | E2 | ||
| S11 | +/– | +/– | 53 | 1 | 1 | 1 | 1 | Box A, ATF, CREB, AP1 | E1 | ||
| S12 | + | + | 62 | 1 | Nrf1 | E2 | |||||
| S13 | – | +/– | 61 | 1 | 1 | AP1 | E1 | ||||
| S14 | – | – | 62 | 3 * | 1 | AP1 | E2 | ||||
| S15 | +/– | +/– | 52 | 1 | 1 | 1 | Nrf1 | E1e | |||
| S15a | +/– | +/– | 59 | 1 | 2 | 1 | Box A | E2 | |||
| S16 | – | +/– | 74 | 2 * | 2 | Nrf1 | E1 | ||||
| S17 | +/– | + | 60 | 1 | 1 | 2 | 1 | E1e | |||
| S18 | + | + | 64 | 3 | 1 | ATF, CREB | E1e | ||||
| S19 | +/– | +/– | 72 | 1 | 1 | Box A (2) | E2 | ||||
| S20 | + | + | 63 | 1 | 1 | E1e | |||||
| S21 | + | +/– | 52 | 3 | 1 | E2 | |||||
| S23 | – | – | 65 | 1 | 1 | 1 | E1e | ||||
| S24 | + | + | 59 | 1 | 1 | 2 | E1e | ||||
| S25 | – | – | 56 | 1 | 1 | E1e | |||||
| S26 | + | + | 53 | 1 | E1e | ||||||
| S27 | + | + | 71 | 2 | 1 | 1 | E1 | ||||
| S27a | – | – | 57 | 1 | 1 | 1 | E2 | ||||
| S28 | + | + | 67 | 1 | 1 | 1 | 1 | AP1 | E1 | ||
| S29 | – | – | inc | E1 | |||||||
| S30 | – | – | 68 | 4 | 1 | ATF, CREB | E2 | ||||
| L3 | + | + | 56 | 2 | 1 | 1 | 1 | E1e | |||
| L4 | + | + | 68 | 2 | E1e | ||||||
| L5 | + | + | 62 | 1 | 1 | E1e | |||||
| L6 | +/– | +/– | 62 | 1 | 1 | 1 | E2 | ||||
| L7 | +/– | +/– | 69 | 1 | 1 | Nrf1 | E1 | ||||
| L7a | + | + | 51 | 2 | 1 | 1 | 1 | Box A*, B | E1e | ||
| L8 | +/– | +/– | 50 | 1 | 1 | 1 | 1 | 1 | AP1 | E2 | |
| L9 | – | – | 57 | 1 | ATF, CREB (2) | E2 | |||||
| L10 | + | + | 60 | 1 | E2 | ||||||
| L10a | + | + | 55 | Box A, Nrf1 | E1 | ||||||
| L11 | +/– | +/– | 64 | 1 | 1 | 1 | E2 | ||||
| L12 | + | + | 73 | 1 | Box A | E1 | |||||
| L13 | – | +/– | 55 | 1 | 1 | E2 | |||||
| L13a | +/– | +/– | 67 | 2 | 2 | 1 | ATF, CREB, AP1 | E1 | |||
| L14 | +/– | +/– | 58 | 2 | 1 | Nrf1 | E1e | ||||
| L15 | – | – | 66 | 1 | 1 | 1 | 2 | E2 | |||
| L17 | – | – | 69 | 1 | 1 | 1 | Box A | E2 | |||
| L18 | – | – | 51 | 1 | 2 | ATF, CREB, AP1 | E1e | ||||
| L18a | – | – | 67 | 1 | 1 | E1 | |||||
| L19 | +/– | +/– | 65 | 1 | 1 | E1 | |||||
| L21 | – | – | 62 | 1 | 1 | E2 | |||||
| L22 | – | – | 61 | E1 | |||||||
| L23 | + | + | 64 | 1 | 1 | 1 | E1 | ||||
| L23a | +/– | +/– | 63 | 1 | Box A | E1 | |||||
| L24 | +/– | +/– | 56 | 1 | 1 | E1 | |||||
| L26 | +/– | +/– | 64 | 1 | 1 | 2 | Box A | E2 | |||
| L27 | – | – | 66 | 3 | 1 | 1 | E2 | ||||
| L27a | – | – | 56 | 1 | 1 | 1 | Box A | E1e | |||
| L28 | + | +/– | 56 | 2 | 1 | 1 | 1 | E2 | |||
| L29 | +/– | +/– | 68 | 2 | 1 | 1 | E1e//2 | ||||
| L30 | – | – | 60 | 2 * | 1 | 1 * | RFX1* Gamma* | E2 | |||
| L31 | – | – | 62 | 1 | 1 | E2 | |||||
| L32 | – | – | 68 | 1 * | 1 * | 1 * | Gamma * | E2 | |||
| L34 | – | – | 55 | 1 | 1 | 2 | 1 | E2 | |||
| L35 | – | – | 59 | 2 | 4 | 1 | E1e | ||||
| L35a | – | – | 64 | 1 | 1 | 1 | E2 | ||||
| L36 | +/– | + | 51 | 1 | 1 | E2 | |||||
| L36a | + | + | 62 | 1 | 2 | 2 | 1 | E1e | |||
| L37 | + | – | 60 | 2 | 2 | 1 | 1 | 2 | E1e | ||
| L37a | +/– | +/– | 52 | 1 | Nrf1 | E1e | |||||
| L38 | +/– | – | 62 | 2 | E2 | ||||||
| L39 | – | +/– | 61 | 1 | 1 | 1 | 1 | E1e | |||
| L40 | – | – | 62 | 2 | 3 | ATF, CREB | E2 | ||||
| L41 | + | + | 54 | 1 | 1 | 1 | ATF, CREB, AP1 | E2 | |||
| LP0 | + | + | 59 | 1 | E2 | ||||||
| LP1 | +/– | +/– | 62 | 1 | E1 | ||||||
| LP2 | +/– | – | 55 | 1 | E2 | ||||||
Bolded numbers indicate that the sites are aligned in orthologous human and mouse genes. An asterisk indicates that there is experimental evidence for the functionality of one or more of the sites.
‡ From –200 to +100 relative to the tsp.
† E1, within Exon 1; E1e, at the extreme 3' end of Exon 1; E2, within Exon 2. The locations are conserved in all rp genes except rpL29 .