Fig 6. Recognition of endogenously processed HBV peptides by TCR-transduced T cells.

After retroviral transduction with respective TCRs, CD8⁺ and CD4⁺ T cells were separated by MACS. Specific lysis of HBV-replicating HepG2.2.15 hepatoma cells or T-cell activation (indicated by IFN-γ secretion) by TCR-transduced CD8⁺ (A) or CD4⁺ (B) T cells was measured. The x-axis indicates the decreasing ratio of TCR⁺ effector to target cells. Each color represents one TCR. Data are presented as mean values +/- SEM from triplicate co-cultures.