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. 2017 Jul 27;13(7):e1005686. doi: 10.1371/journal.pcbi.1005686

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© 2017 Yildirim et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — Fura-2 Ca²⁺ measurements from wild-type (A) and SUR1^-/- islets (B) at 11 mM glucose. The change in Ca²⁺ is expressed as the Fura-2 340/380 ratio. (C) Comparison of I-V curves from wild-type (black) and SUR1^-/- (red) β-cells. The wild-type recording is representative of n = 6 islets isolated from 4 mice. The SUR1^-/- recording is representative of n = 8 islets isolated from 5 mice. The SUR1^-/- islets exhibited significant inward rectification at more negative potentials compared to cells from wild-type islets.