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Putative scheme of the effect of the CXCR3/CXL10 interactions in the lung of hypersensitivity patients. As a consequence of the antigenic stimulation APC release IFN-γ. This cytokine stimulates AM to release CXCL10, a chemokine which favours the recruitments of activated CD8(+) /CXCR3(+) Tc1 lymphocytes. These cells, which release IFN-γ, in turn contribute to maintain the activation state of APC at sites of hypersensitivity reaction.
