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. 2001 Jul 31;98(17):9599–9604. doi: 10.1073/pnas.171311298

Figure 5.

Figure 5

HCV nonstructural protein induced NF-κB-controlled luciferase expression. (A) Dose-dependent activation of NF-κB by HCV nonstructural proteins (pCMV729-3010) as described in Fig. 4. (B) Antioxidants and calcium chelators inhibit the transcriptional activation of NF-κB-controlled luciferase expression by HCV nonstructural proteins. Cells were transfected with 4 μg of pCMV729-3010 vector and Mn-SOD or were treated with NAC (30 mM) and PDTC (100 μM) for 6 h and TMB-8 (100 μM) for 45 min before preparing lysates for luciferase activity, respectively.