Table 2.

Summary of tissue pathology

Animal	Hipp	Cbllm	Ctx	Striatum	Olf Bulb	Med/Th/BS	Lung	Liver
Treated #1	++++	++++	+	+++	++	+	++++	++++
Treated #2	+	0	+	++	+	+	+	0
Het	+	++	0	+	+	0	0	0
MPS I	++++	++++	+	+++	+++	+	++++	++++

Stained sections were evaluated for presence of pathologic storage vesicles under blinded conditions. The grading scheme describes the distribution of affected cells as a proportion of total cells. For the lung, the evaluation was as a proportion of total macrophages present, while for the cerebellum it was assessed in Purkinje cells only.

0, no cytoplasmic vacuoles; +, cytoplasmic vacuoles in <10% of cells; ++, cytoplasmic vacuoles in 10–25% of cells; +++, cytoplasmic vacuoles in 25–50% of cells; ++++, cytoplasmic vacuoles in >50% of cells.