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. 2017 Aug 1;14(4):293–304. doi: 10.1089/zeb.2016.1398

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Copyright 2017, Mary Ann Liebert, Inc.

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FIG. 1. — Generation of Tg(Bre:GFP); Tg(acvr1l_Q204D-mCherry) animals. A Yelick laboratory-created construct for constitutively active zebrafish acvr1l contains 2 bp mutations converting a CAG to GAC in exon 4 (A). These mutations result in an amino acid change of glutamine (Q) 204 to aspartic acid (D) in the GS domain of the zebrafish Acvr1l protein (B). Zebrafish Acvr1l p.Q204D is homologous to human ACVR1 p.Q207D, which is one of the variants (along with p.R206H) in the GS domain commonly mutated in FOP patients. (C) Schematic of pDestTol2pA2 constructs to generate Tg(hsp70l:acvr1l-mCherry) and Tg(hsp70l:acvr1l_Q204D-mCherry). FOP, fibrodysplasia ossificans progressiva; GS, glycine-serine.