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. 2017 Jul 17;13:1744806917723789. doi: 10.1177/1744806917723789

Figure 2.

Figure 2.

Changes of the NR1, NR2B, p-NR1, and p-NR2B expression after drugs administration in DH neurons. In (a) and (b), sham represents baseline, no drugs treatment; Remi represents 4 nM remifentanil treatment 60 min; 1 h, 2 h, 4 h, and 8 h, respectively, represents 1 h, 2 h, 4 h, and 8 h remifentanil washout ((a) and (b)). In (c) and (d), sham represents baseline, no drugs treatment; Remi represents 4 nM remifentanil treatment 60 min; 1 h represents 60 min remifentanil washout and KN93 treatment 1 h; 2 h represents 60 min remifentanil washout and KN93 treatment 2 h; 4 h represents 60 min remifentanil washout and KN93 treatment 4 h; 8 h represents 60 min remifentanil washout and KN93 treatment 8 h; In (e) and (f) and (g) and (h), treatment protocols of chelerythrine and PD98059 are the same to that in (c) and (d). Data are expressed as means ± SD; n = 5 per group per time point.*p < 0.05 vs. Control, #p < 0.05 vs. Remi. Values for NMDA subunits expression were presented as fold increase over group sham and normalized to the expression of GAPDH.