Table 2. Neutralization of tier-1 and tier-2 viruses in TZM-bl cell assaya.
| Tier 1A | Tier 2 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clade B | Clade C | Clade A | Clade C | Clade B | CRF07 BC | Clade B | Clade C | Clade AC | CRF07 BC | Clade A | CRF01 AB | ||||
| Regimen | Animal ID | Bleed Week | Negative Control | MN.3 | MW965.26 | BG505ΔCT/T332N | 25710–2.43 | TRO.11 | BJOX002000.03.2 | X1632-S2-B10 | Ce1176 A3 | 246-F3 C10 2 | CH119.10 | Ce703010217 B6 | CNE55 |
| CC | M17 | 10 | <20 | 558 | 2819 | 73 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| M19 | 10 | <20 | 554 | 895 | 70 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| M23 | 10 | 34 | 584 | 1207 | 40 | 32 | 32 | 28 | 35 | 28 | 35 | 40 | 27 | 24 | |
| F2 | 10 | <20 | 714 | 802 | 33 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F21 | 10 | <20 | 635 | 1690 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | 584 | 1207 | 40 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
| CCC | M17 | 26 | <20 | <20 | 189 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| M19 | 26 | <20 | <20 | 76 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| M23 | 26 | <20 | <20 | <20 | 36 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F2 | 26 | <20 | <20 | 65 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | <20 | 71 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
| MMM | M8 | 26 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| F20 | 26 | <20 | <20 | 710 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F31 | 26 | <20 | <20 | <20 | 311 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
| PPP | M10 | 26 | <20 | 496 | 5296 | 559 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| M12 | 26 | <20 | 112 | 2171 | 925 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| M27 | 26 | <20 | 61 | 2385 | 45 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F4 | 26 | <20 | 121 | 13856 | 150 | 80 | 29 | <20 | <20 | 77 | <20 | <20 | <20 | <20 | |
| F13 | 26 | <20 | 1714 | 33189 | 41 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | 117 | 5296 | 150 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
| CPP | M7 | 26 | <20 | 235 | 8618 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| F5 | 26 | <20 | 879 | 1397 | 151 | 27 | 21 | <20 | <20 | 39 | <20 | <20 | <20 | <20 | |
| F6 | 26 | <20 | 325 | 13309 | 553 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F22 | 26 | <20 | 87 | 8532 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | 280 | 8575 | 76 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
| MPP | M9 | 26 | <20 | 467 | 1770 | 125 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| M15 | 26 | <20 | 521 | 8599 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| M18 | 26 | <20 | 1026 | 6008 | 400 | 42 | <20 | <20 | <20 | 45 | <20 | <20 | <20 | <20 | |
| F29 | 26 | <20 | 137 | 847 | 847 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | 494 | 3889 | 263 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
| CM | M11 | 10 | <20 | 1130 | 940 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| F1 | 10 | <20 | 20545 | 11454 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F3 | 10 | <20 | 540 | 2770 | 90 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F26 | 10 | <20 | 6558 | 2732 | 28 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| M16 | 10 | <20 | 2070 | 2071 | 245 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | 2070 | 2732 | 28 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
| CMP | M11 | 26 | <20 | 468 | 1470 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 |
| F1 | 26 | <20 | 343 | 8624 | 37 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F3 | 26 | <20 | 397 | 6355 | 2096 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| F26 | 26 | <20 | 6199 | 24627 | 1011 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | |
| median | <20 | 432 | 7490 | 524 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | <20 | ||
a—Values are the serum dilution at which relative luminescence units (RLUs) were reduced 50% compared to virus control wells (no test sample). Highlighted bold values are considered positive for neutralization based on the criterion of signal ≤3x the signal of that sample against the MLV-pseudotyped negative-control virus.