Table 2.
Allele and genotype frequencies of rs1498608 in high and low lumbar spine BMD groups.
| Sample | Allele/Genotype | Low N (Rel. Freq.) | High N (Rel. Freq.) | OR (95% C.I.) | P-value |
| Discovery (UK) | |||||
| Female | A | 52 (0.086) | 77 (0.123) | 0.035a | |
| T | 550 (0.914) | 547 (0.877) | 1.5 (1.0, 2.2) | ||
| AA | 1 (0.003) | 9 (0.029) | 0.026b | ||
| AT | 50 (0.166) | 59 (0.189) | 7.6 (0.99, 340) | 0.042c | |
| TT | 250 (0.831) | 244 (0.782) | 9.2 (1.3, 410) | 0.020c | |
| Replication (AUS) | |||||
| Female | A | 15 (0.054) | 30 (0.109) | 0.018a | |
| T | 261 (0.946) | 244 (0.891) | 2.1 (1.1, 4.4) | ||
| AA | 0 (0.000) | 3 (0.022) | 0.048b | ||
| AT | 15 (0.109) | 24 (0.175) | 4.4 (0.23, ∞) | 0.541c | |
| TT | 123 (0.891) | 110 (0.803) | 7.8 (0.45, ∞) | 0.108c | |
| Male | A | 9 (0.132) | 13 (0.191) | 0.352a | |
| T | 59 (0.868) | 55 (0.809) | 1.6 (0.56, 4.5) | ||
| AA | 1 (0.029) | 3 (0.088) | 0.754b | ||
| AT | 7 (0.206) | 7 (0.206) | 3.0 (0.17, 180) | 0.588c | |
| TT | 26 (0.765) | 24 (0.706) | 3.3 (0.24, 180) | 0.610c | |
Abbreviations: Rel. Freq., relative frequency; OR, odds ratio; C.I., confidence interval. Odds ratios for the AT and TT genotypes are contrasted against the AA genotype. aChi-square test of heterogeneity comparing allele frequencies between high versus low. bFisher's exact test comparing three genotype frequencies between high versus low. cFisher's exact test comparing genotype frequencies in current table row and AA genotype between high versus low.