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. 2017 Aug 9;12(8):e0182804. doi: 10.1371/journal.pone.0182804

Fig 5. Aβ42 G37L protects from Aβ42 toxicity as dominant negative.

Fig 5

Aβ42 G37L Protects from Toxicity as Dominant Negative at high concentrations. Wild-type recombinant Aβ42 was mixed in an equimolar ratio with Aβ42 G37L. PC12 cells were treated for 24 hours and viability was assayed by MTT. Bars represent 6 biological replicates. Error bars represent SEM. A pairwise T-test across all dose series gave an insignificant p = 0.06 comparing the recombinant (REC) and recombinant doped with the G37L mutant (REC + G37L). At the highest concentrations, however a significant protective affect was observed, 25nM p = 0.01, 65nm p = 0.0001.