Skip to main content
. 2017 Aug 9;12(8):e0182415. doi: 10.1371/journal.pone.0182415

Fig 3. TNFR1 expression after infection is functional in induction of monocytic apoptosis.

Fig 3

TNFR1 expression on the plasma-membrane of PBMO and CBMO before and after infection depicted as mean expression of TNFR1 on all monocytes (A, n = 6; *p < 0.05, **p < 0.01, ***p < 0.005, clamped bars, student`s t-test; blunt-ended bars, two-way ANOVA). To groups indicated, the metalloprotease inhibitor GM6001 was added. TNF-α secretion is diminished by GM6001 (B, n = 3; *p < 0.05, **p < 0.01, ***p < 0.005, clamped bars, student`s t-test). Detection of apoptotic PBMO and CBMO after infection and/or addition of GM6001 and TNF-α (C, n = 8, *p < 0.05, **p < 0.01, clamped bars, student`s t-test *within bars, p < 0.005, two-way ANOVA).