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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: J Labelled Comp Radiopharm. 2017 Jun 14;60(9):450–456. doi: 10.1002/jlcr.3519

Table 4.

Radiosynthesis of methyl 4-bromobenzoate

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Entry Precursor (mg) H2O (μL) Solvent (500 μL) Microwave (30 sec)
Yield (%) [Ratio]1
1 5 / DMF 70/23
2 2.5 / DMF 69/232
3 0.5 / DMF 70/18
4 2.5 50 DMF 64/25
5 2.5 100 DMF 63/19
6 2.5 1003 DMF 76/19
7 2.5 / DMSO 75/22
8 4 / DMSO4 77/19
9 5 / DMF5 77/20

Notes:

1

Yield of methyl 4-bromobenzoate/bromobenzene by radioTLC and HPLC;

2

96% (+30 sec microwave), and 97% (+60 sec microwave);

3

With KBr (100 μg);

4

[6Br]bromide after 7 half-lives;

5

MQA method was used to elute radioactivity (0.5 mCi) with 8 in DMF (5×1 mg/0.1 mL) in 98% efficiency. Reaction condition: microwave 2×30 sec with interval of 30 sec.