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. 2017 Jul 27;9(2):654–666. doi: 10.1016/j.stemcr.2017.06.016

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Structures with Diverse Size Induced Distinct Morphological Changes in iPSCs

(A and B) Confocal microscopy images of single iPSCs (A) and iPSC colonies (B) seeded on PDMS substrates that were structured with grooves of different periodicities. Cells were stained for actin (green) and nuclei (blue). The dotted white arrows indicate the direction of the submicron grooves. Scale bars, 20 μm in (A) and 50 μm in (B).

(C and D) Analysis of nuclear and cellular aspect ratio for single iPSCs (C) and whole iPSC colonies (D) when seeded on the PDMS submicron-grooved substrates. Data are presented as mean ± SD (n = 3 independent biological replicates, ^∗∗∗p < 0.001).