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. Author manuscript; available in PMC: 2017 Aug 9.
Published in final edited form as: Neuroscience. 2015 Jul 23;309:233–242. doi: 10.1016/j.neuroscience.2015.07.038

Figure 1. Model showing REST-dependent epigenetic remodeling of the grin2b promoter.

Figure 1

REST binds to the RE1 element within the promoter of its target gene grin2b and recruits mSin3A and CoREST, HDACs-1/2, G9a and MeCP2. The REST-corepressor complex promotes epigenetic remodeling of core histone proteins at the grin2b promoter. Recruitment of EZH2 in the promoter of grin2b confers trimethylation on lysine 27 of core histone protein H3. These may play a crucial role in acquisition of the mature NMDAR phenotype during postnatal development. Modified with permission from Noh et al, Proc Natl Acad Sci USA 109:E962-7.