Figure 2.

Weighted Gene Coexpression Network Analysis of hOPC Differentiation

(A and B) Analysis of network topology to determine soft-thresholding power. (A) Fit of power-transformed gene-pairwise Pearson correlation to scale-free topology as a function of soft threshold. (B) Mean network connectivity as a function of soft threshold. Soft-thresholding power of 8 was selected to maximize the model fit.

(C) Heatmap of Pearson correlation between eigengenes of WGCNA modules.

(D) Expression profiles of merged module eigengene illustrate distinct expression patterns in final network.

(E) Correlation of module eigengenes with experimental variables: time, culture condition (PDGF-AA, noGF), and their interaction.