Figure 3.

Conservation of OPC and Oligodendrocyte WGCNA Modules between Species

WGCNA was performed on rat oligodendrocytes (OLGs) (Dugas et al., 2006), isolated mouse OPCs/OLGs (Cahoy et al., 2008), and isolated hOPCs (Abiraman et al., 2015). Following module overlap analysis between these datasets, only five modules exhibited substantial and significant overlap (p < 0.05, FDR-corrected hypergeometric test).

(A) Heatmap of eigengene expression for the five modules.

(B–F) Relative enrichment of shared genes in each matching module (compared with random list) and corresponding hypergeometric test p value. Eigengene expression profiles of cross-species-conserved modules M15 and M5 in differentiating hOPCs (C), human isolated OPCs (D), rat differentiating OPCs (E), and isolated mouse OPCs/OLGs (F). Mean ± SEM.