Video 3. A simulation of the theoretical model of macular development driven by a stem-cell population.
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DOI: 10.7554/eLife.25681.042
In this variant of the elasticity-limited model, a patch of stem cells (blue) proliferates and differentiates into supporting cells (green). The model assumes that only stem cells divide (white). The model predicts that stem cells at the center of the utricular macula can proliferate only briefly before cellular density increases and precludes further divisions. Although some stem cells are advected towards the macular periphery, the pattern of proliferation is not consistent with that observed in vivo.